Subject(s)
Carcinoma, Transitional Cell/etiology , Carcinoma, Transitional Cell/pathology , Female , Humans , Middle Aged , Neoplasms, Second Primary/etiology , Neoplasms, Second Primary/pathology , Radiotherapy/adverse effects , Urinary Bladder Neoplasms/etiology , Urinary Bladder Neoplasms/pathology , Uterine Cervical Neoplasms/radiotherapyABSTRACT
Transitional cell carcinoma [TCC] of the bladder remains a significant health problem worldwide. The molecular mechanisms of tumor development and progression are complicated but likely involve the interaction of tumor suppressor genes, oncogenes, cell cycle regulatory proteins and other factors. Hence, this study attempts to explore the role of nuclear factor-kB [NF-KB] in the TCC of the bladder in correlation with different clinicopathological criteria which are tumor grade, muscle invasion by the tumor, schistosomiasis and presentation whether primary or recurrent tumor. Twenty patients with TCC of the bladder were included in the study from June 2003 to June 2004, and were diagnosed by histopathology. The expressions of the transcription factor NF-kB were studied by in situ hybridization technique [ISH]. The results showed that there was a significant correlation [p<0.05] with muscle invasion and schistosomiasis but not with other criteria. The current study showed the possible role of the transcription factor [NF-kB] in TCC of the bladder
Subject(s)
Humans , Male , Female , Carcinoma, Transitional Cell/etiology , NF-kappa B/adverse effects , In Situ Hybridization , SchistosomiasisABSTRACT
A case of transitional cell carcinoma of the urinary bladder that was excised twenty years ago presented as an unusual dissemination to the left iliac muscle. The probable route of metastasis is discussed and the relevant literature is reviewed